NMPFamsDB is a database which hosts novel metagenome protein clusters with no or weak hits to Pfam or Reference genomes and aiming at significantly expanding the protein family space known till today. With NPFamsDB you can:

• Explore the novel protein families and their genomic content
• See their habitat distribution
• Follow their biogeographical trademarks
• See their taxonomy information
• Explore potential novel structures and folds
• Use HMM and sequence-based searches for querying the protein clusters
• Filter information by smart filters at any stage of analysis

The identified novel protein clusters, contained in NMPFamsDB, significantly expand (at least double) the number of protein sequence clusters currently available and reveal new insights into their habitat distribution, origins, functions and taxonomy. We expect NMPFamsDB to be a valuable resource for proteome-wide analysis and for the further study of metagenomes.